eP596 - C-Reactive Protein as Early Predictor of Anastomotic Leak After Elective Colorectal Cancer Surgery in a Tertiary Chilean Hospital

Monday, June 3, 2024

10:54 AM – 10:59 AM ET, USA

Location: Baltimore Convention Center, Room 318-320

ePoster Presenter(s)

Jorge Escarate

Colorrectal surgeon
Hospital regional de rancagua
Universidad de O'Higgins
Rancagua, Libertador General Bernardo O'Higgins, Chile

All of the relevant financial relationships listed below have been mitigated.
This individual has no financial relationships with ineligible companies.

Senior Author(s)

Gustavo J. Montesinos

Colorectal Surgery
Hospital Regional de Rancagua
Requínoa, Libertador General Bernardo O'Higgins, Chile

All of the relevant financial relationships listed below have been mitigated.
This individual has no financial relationships with ineligible companies.

Author(s)

PC

Paz Cardenas, Hospital libertador Bernardo O'Higgins

Intern of medicine
Universidad de O'Higgins
Nacimiento, Bio-Bio, Chile

Disclosure information not submitted.
PL

Paulina A. Leyton, Hospital Regional Libertador Bernardo OHiggins

Intern of Medicine
Universidd de OHiggins
Rancagua, Libertador General Bernardo O'Higgins, Chile

Disclosure information not submitted.
VF

Valentina P. Fernández, n/a

Intern of Medicine
Universidad de O'Higgins
Santiago, Region Metropolitana, Chile

Disclosure information not submitted.

Author(s)

CS

Catalina Saavedra Gonzalez

Disclosure information not submitted.

Author(s)

JV

Joaquin A. Vega, n/a

Medical Student
Universidad de O´Higgins
Rancagua, Libertador General Bernardo O'Higgins, Chile

Disclosure information not submitted.

Purpose/Background: Anastomotic leak corresponds to a severe postoperative complication in colorectal surgery, causing an increase in mortality, morbidity and in-hospital stay. C-reactive protein has been used as an indicator of anastomotic leakage and as a marker for early discharge support, although this has not been validated locally.

Objective: To determine the correlation of C-reactive protein with anastomotic leak and whether it is useful as a predictor of anastomotic leak in post-operative colorectal cancer patients at Hospital Regional del Libertador Bernardo O´Higgins, Rancagua, Chile (HRLBO).Methods/Interventions: A prospective observational study design was performed. From June 2017 to December 2022, a consecutive series of patients with colorectal cancer that underwent elective surgery with anastomosis in our Hospital was included, with a total of 345 patients. GraphPad Prism 8 software was used for statistical analyses, performing ROC curve and chi-square tests.Results/Outcomes: We found that 22 (9.2 %) of the studied population had anastomotic leakage. It was determined that a CRP value < 19.68 mg/dL allows ruling out an anastomotic leak (ROC: 0.91, p < 0.0001). Additionally, it was established that the difference between the fourth and second day CRP was -1.675 mg/dL (ROC: 0.76, p = 0.0004). Forty-five percent of the cases that presented anastomotic leaks corresponded to low colorectal anastomosis surgeries.Conclusion/

Discussion: In our study population, fourth day CRP had a higher predictive value than the difference between second- and fourth-day CRP. The measurement of CRP is useful as a predictor of anastomotic leakage, which is consistent with the known evidence, occurring more frequently in low colorectal cancer. This represent our initial experience in measuring and stablishing CRP cut-off for safely early discharge with good results. We expect to continue increasing our database for more robust data onfoward.